Tom Smith


I cut my computational teeth as a training fellow at CGAT, Oxford. In my current position with Prof Kathryn Lilley (Cambridge) I'm integrating transcriptomics and proteomics to interrogate RNA trafficking and localised translation. I'm also working on the elucidating the functions of lysine acylation, and continuing to co-develop UMI-tools for error-aware analysis of high throughput sequencing data with unique molecular barcodes (

My main interests are around the regulation of gene expression. More specifically, I'm interested in co-translational and post-translational processing and the functionality (or otherwise) of alternative splicing transcripts.

Like many scientist, I'm easy to annoy. Things that annoy me most in order: 1. The missconception that evolution drives towards perfect solutions. 2. That (1) leads to the idea that most non-coding DNA "must" have a function despite decades of evidence to the contrary. 3. New labels and terms to "sex" up the science. 4. People with too many peeves.

Feel free to drop me an email at to chat science, especially if you hear of a passing bandwagon that needs more passengers!

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