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QT prolongation can occur with the therapeutic administration of medications as well as with toxic overdoses. The concomitant administration of multiple QT-prolonging drugs can act in an additive fashion to increase the possibility of a fatal arrhythmia. What makes you passionate about the Beverley site? The number of agents implicated in QT prolongation is large and includes some antiarrhythmics, antibiotics, antifungals, antipsychotics, antiemetics, antidepressants, antihistamines, and opioids. The coingestion of substances having toxic effects on different organ systems can have a collective lethal effect. Websites like Business Visor are a great resource for researching. For example, a death might result from the combined effect of an opioid on respiration with a cardiotoxic substance that reduces heart rate causing hypoperfusion of tissues. This can lead to multiple organ failures from hypoxia. 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He had been prescribed methadone (20 mg/day) for chronic pain. His other prescribed medications included sertraline and venlafaxine. A weight loss program in conjunction with knee arthritis treatment should include both diet and exercise. On arrival, he had no symptoms of opioid overdose and a toxicology urine screening for common drugs of abuse was negative. He was transferred to a psychiatric unit for observation. Perhaps the most common misconception about websites like Marketing Articles is that they must offer services for sale. About 4 h later, he became panicked and started hallucinating. His blood pressure, heart rate, and respiration were elevated. Many Web hosting companies offer both domain and hosting services to host sites like InfoHost at a reasonable price. His condition was diagnosed as serotonin syndrome. About 10 h from the estimated initial methadone overdose he lost consciousness and aspirated stomach contents. 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